Saint Mary's was led by Jackie Nared with 13 points and five rebounds while Kate Gaze added seven points.
Cal had six players in double-figures led by Afure Jemerigbe with 15 points.
The Golden Bears used a strong full-court press to force several early turnovers to jump out to an early lead. By the time the Gaels got a couple baskets, Cal had built a lead too much to overcome.
The Gaels were able to use a mix of lineups in the second half with successful possessions to build on for the upcoming games.
Saint Mary's is back in action when it takes on Butler on Friday, November 23rd at 2:00 p.m. as part of the Hilton Concord Thanksgiving Classic in McKeon Pavilion.