The Bears improve to 37-1 with the win, while Saint Mary's drops to 15-20 this season.
California took an early 2-0 lead in the top of the first after three singles by the Bears.
The Bears added to their lead in the top of third. After Jace Williams walked to open the inning, Breana Kostreba hit a blast over the right field fence to give Cal a 4-0 lead.
SMC starting pitcher Jessica Lemmon's day ended after the home run and she was replaced on the mound by freshman Sarah Lira. Lemmon's (8-9) line for the day was 2.0 innings pitched, allowing four hits and four earned runs with four walks and a strikeout.
California added to their lead in top of the fourth to go up 5-0. Jamia Reid walked to open the inning and then stole second and third before Britt Vonk grounded out to second base to bring her home.
The Gaels had their best chances of the game in the fourth and sixth innings when they registered two singles in each inning, but Cal was able to get out of the inning each time.
The Bears extended the lead to 7-0 with single runs in both the fifth and sixth innings. Cal then added two unearned runs in the top of the seventh off senior Kimberly Green to give them a 9-0 final advantage.
Saint Mary's will return to action this weekend with a four-game PCSC series on the road against CSU Bakersfield. The Gaels and Roadrunners will play doubleheaders on Saturday, April 14 and Sunday, April 15, with games on both days beginning at 12 p.m.