With the loss, Saint Mary's drops to 1-6, while Quinnipiac improves to 1-1.
In addition to Cross' six scores, Mariah Walk added three goals while Krista Morgan scored twice. Jaclyn Biggers, Caroline Mahony and Jillian Chong also scored for SMC.
The Gaels trailed 10-6 at halftime and were outshot 20-14 by the Bobcats. Saint Mary's chipped away in the second-half, coming within two goals on several occasions. Trailing 14-11, the Gaels got two goals from Cross and the equalizer from Walk with 8:06 remaining and the score at 14-14.
Quinnipiac withstood the SMC run however, as the Bobcats scored the games' final four goals. QU took the lead 15-14 with 7:28 remaining, then added goals at the 5:50 mark, 1:53 and :56 second marks to win the game by an 18-14 score.
The Gaels did have two leads in the first half as Mahony gave SMC its first lead with 26:54 remaining at 3-2. Later, Biggers scored at the 22:29 mark to give SMC a 5-4 advantage. Quinnipiac outscored SMC 6-1 to end the first half for the 10-6 lead at the break.
Saint Mary's is back in action on Thursday when it hosts Long Island University at 3:30 p.m. at Recreation Field.